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Offering hope and changing lives
Clinical research helps us identify new therapeutic options that make our lives healthier and safer. Novel therapies are scrutinized through the clinical trial process prior to receiving FDA approval to confirm their safety, effectiveness, and quality before getting approved for public use. Through our innovative clinical research studies, we gain insights and answers to advance new preventions, treatments, and sometimes cures. We serve as a gateway for researchers to advance science and clinical knowledge. Our basic, clinical, and translational research brings the most advanced care to our patients and community.
Clinical research is a vital component to caring for our community. Our culture promotes innovation and collaboration with academic, industry, government, and philanthropic partners. Research is the intersection of hope, innovation, and science.
Adult research and clinical trials
Cardiovascular
Cardiothoracic surgery and vascular
- Randomized controlled clinical trial on the application of Heli-FX EndoAnchors in conjunction with the Endurant II/IIs endograft in infrarenal aortic aneurysms with a wide infrarenal neck
- Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts: the ROMA trial.
- stAAAble Trial: Randomized Controlled Clinical Trial (RCT) of the Nectero EAST System for Small to Mid-Sized Abdominal Aortic Aneurysms (AAA) StaBiLization: Evaluation of Efficacy.
Interventional (coronary artery disease)
- A Randomized, Comparative Effectiveness Study of Complete Revascularization with Percutaneous Coronary Intervention to Treat Coronary Artery Disease vs Medical Management Alone in Patients with Symptomatic Aortic Valve Stenosis undergoing Elective Transfemoral Transcatheter Aortic Valve Replacement: The COMPLETE TAVR Study
- An adaptive phase 2/3 multicenter, double/blind, placebo-controlled, parallel, 3 arm study to evaluate the efficacy and safety of DA-1229 (evogliptin) in patients's calcific aortic valve disease with mild to moderate aortic stenosis (EVOID-AS)
General cardiology
Electrophysiology (heart rhythm disorders)
- REACT-AF: The Rhythm Evaluation for AntiCoagulaTion with Continuous Monitoring of Atrial Fibrillation
- Real-world Experience of Catheter Ablation for the Treatment of Symptomatic ParoxysmaL and Persistent Atrial Fibrillation Using Novel CARTO Technologies: REAL AF Registry
- Assessment of Safety and Effectiveness in Treatment Management of Paroxysmal Atrial Fibrillation with the BWI Pulsed Field Ablation System with OMNYPULSE™ Catheter (OMNY-AF)
- Posterior Wall Substarte Modification Using Irreversible Electroporation for the Treatment of Paroxysmnal Atrial Fibrillation (SIMLE-AF)
Structural heart
- AltaValve™ Pivotal Trial Protocol
- Edwards PASCAL TrAnscatheter Valve RePair System Pivotal Clinical Trial (CLASP II TR): A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter tricuspid valve repair with the Edwards PASCAL Transcatheter Valve Repair System and optimal medical therapy (OMT) compared to OMT alone in patients with tricuspid regurgitation
- Percutaneous MitraClipTM Device or Surgical Mitral Valve REpair in PAtients with PrImaRy Mitral Regurgitation who are Candidates for Surgery (REPAIR MR)
- Valve Hemodynamic Optimization Based on Doppler-Echocardiography Versus Catheterization Measurements Following Valve-in-Valve TAVR: A Prospective Randomized Trial. The ECHOCATH Trial.
Emergency medicine
- A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, for Stroke Prevention after an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE
- Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients - A Multicenter, Randomized, Adaptive Clinical Trial to Identify the Optimal Duration of Induced Hypothermia for Neuroprotection in Comatose Survivors of Cardiac Arrest
- Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258) (FASTR-II)
- Evaluating the Role of the Guidewire in Peripheral Intravenous Access: a Randomized Controlled Trial of Ultrasound-Guided Catheter Survival
Infectious disease
- A Randomized, Double-blind, placebo-controlled Phase 3 study of VE303 for prevention of recurrent C. diff infection (276492)
- Optimization of Beta-lactam Dosing in Critically Ill Patients with Suspected or Documented Antimicrobial Resistant Gram-Negative Infections with Cystatin-C (OPTIMIZE-GNI)
- Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab (MEDI3506) in Patients Hospitalized for Viral Lung Infection Requiring Supplemental Oxygen (TILIA)
- A phase 4 study using a test-negative design to evaluate the effectiveness of a 20 valent pneumococcal conjugate vaccine against vaccine type radiologically confirmed community acquired pneumonia in adults ≥65 years of age
Oncology & hematology
Radiation oncology
- A PHASE I/II STUDY OF CARDIAC RADIOABLATION FOR REFRACTORY VENTRICULAR TACHYCARDIA
- A Phase IV, Post-Authorization Safety Study to Investigate the Long-Term Safety of lutetium (177Lu) vipivotide tetraxetan in Adult Participants with Prostate Cancer
- TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer
- A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients With Resectable Brain Metastases
- A Phase III Clinical Trial Evaluating De-Escalation of Breast Radiation for Conservative Treatment of Stage I, Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer
- A Phase III Randomized Trial of Protons Versus Photons for Hepatocellular Carcinoma
- Phase III Randomized Trial of Proton Beam Therapy (PBT) Versus Intensity Modulated Photon Radiotherapy (IMRT) for the Treatment of Esophageal Cancer
- Parallel Phase III Randomized Trials for High Risk Prostate Cancer Evaluating De-Intensification for Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk With Radiation (PREDICT-RT*)
- Parallel Phase III Randomized Trials of Genomic-Risk Stratified Unfavorable Intermediate Risk Prostate Cancer: De-Intensification and Intensification Clinical Trial Evaluation (GUIDANCE)
- The Phase III 'High Five Trial' Five-Fraction Radiation for High-Risk Prostate Cancer
- RAndomized Phase II/III Trial of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR Trial
- Phase III Prospective Randomized Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally-Advanced Non-Small Cell Lung Cancer
- MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)
- A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)
Medical oncology
- A Phase 2 Study of Inotuzumab Ozogamicin (NSC# 772518) in Children and Young Adults With Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia (B-ALL)
- A Phase 3 Randomized Trial of Inotuzumab Ozogamicin (NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy
- A Phase 2 Trial of Chemotherapy Followed by Response-Based Whole Ventricular & Spinal Canal Irradiation (WVSCI) for Patients With Localized Non-Germinomatous Central Nervous System Germ Cell Tumor
- A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors
- A Randomized Phase 3 Interim Response Adapted Trial Comparing Standard Therapy With Immuno-oncology Therapy for Children and Adults With Newly Diagnosed Stage I and II Classic Hodgkin Lymphoma
- A Phase 3 Study of Dinutuximab Added to Intensive Multimodal Therapy for Children With Newly Diagnosed High-Risk Neuroblastoma
- A Randomized Phase 3 Trial of Nivolumab (NSC# 748726) in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma
- Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias
- The Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study
- Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumors (FHWT)
- A Prospective Phase 3 Study of Patients With Newly Diagnosed Very Low-Risk and Low-Risk Fusion Negative Rhabdomyosarcoma
- A Randomized, Open-label, Phase 3 Study of Adjuvant Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy
- APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
- Randomized Phase III Study of Combination Osimertinib (AZD9291) and Bevacizumab Versus Osimertinib (AZD9291) Alone as First-Line Treatment for Patients With Metastatic EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC)
- Molecular Analysis for Combination Therapy Choice (ComboMATCH)
- Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
- Randomized Phase II/III Trial of First Line Platinum/Etoposide With or Without Atezolizumab (NSC#783608) in Patients With Poorly Differentiated Extrapulmonary Small Cell Neuroendocrine Carcinomas (NEC)
- Phase III Trial of Neoadjuvant Durvalumab (NSC 778709) Plus Chemotherapy Versus Chemotherapy Alone for Adults With MammaPrint Ultrahigh (MP2) Hormone Receptor (HR) Positive / Human Epidermal Growth Factor Receptor (HER2) Negative Stage II-III Breast Cancer
- Shorter Anthracycline-Free Chemo Immunotherapy Adapted to Pathological Response in Early Triple Negative Breast Cancer (SCARLET), A Randomized Phase III Study
- A Phase 2 Study of Blinatumomab (NSC# 765986, IND# 147294) in Combination with Nivolumab (NSC # 748726, IND# 147294), a Checkpoint Inhibitor of PD-1, in B-ALL Patients Aged ≥ 1 to < 31 Years Old with First Relapse
Orthopedics
- PAULA - Pelvic fixation and fusion during multilevel spinal surgery
- A Study to Evaluate the Utilization of 3D Printed Models in Pre-Operative Planning
- Zimmer Biomet Shoulder Arthroplasty Long-term Post Market Clinical Follow-up Study
- ONLAY VERSUS INLAY HUMERAL COMPONENT IN REVERSE TOTAL
- A prospective, multicenter study evaluating the safety and performance of interbody implants for the treatment of patients with degenerative conditions of the thoracic and/or lumbar spine
- ONLAY VERSUS INLAY HUMERAL COMPONENT IN REVERSE TOTAL
Pulmonary
Pulmonary fibrosis
- A Randomized, double-blind, Placebo-controlled, Multinational, Phase 3 study of the Efficacy and Safety of Inhaled Treprostinil in Subjects with Progressive Pulmonary Fibrosis (TETON-PPF)
- A randomized, double-blind, placebo-controlled Phase II study to Determine the Safety and Efficacy of Oral Ifetroban in Patients with Idiopathic Pulmonary Fibrosis
Urology
- COMPARISON OF BLADDER DIRECTED AND PELVIC FLOOR THERAPY IN WOMEN WITH INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME
- THE EFFECT OF ACUTE PERI-URETHRAL NEUROSTIMULATION ON INTRA-URETHRAL PRESSURE IN WOMEN WITH STRESS URINARY INCONTINENCE (SUI)-URODYNAMIC EARLY FEASIBILITY STUDY
- A SINGLE-BLIND, RANDOMIZED STUDY OF THE BTL EMSELLA TM CHAIR VERSUS SHAM FOR THE TREATMENT OF MALE SEXUAL DYSFUNCTION
- A SINGLE-BLIND, RANDOMIZED STUDY OF THE BTL EMSELLATM CHAIR VERSUS SHAM FOR THE TREATMENT OF OVERACTIVE BLADDER
- A SINGLE-BLIND, RANDOMIZED STUDY OF THE BTL EMSELLA CHAIR VERSUS SHAM FOR THE TREATMENT OF STRESS URINARY INCONTINENCE
- Laparoscopic TAP Block During Robotic Assisted Laparoscopic Radical Prostatectomy for Improvement in Postoperative Pain (TAPBlock)
- Sacral Neuromodulation for the Management of Chronic Pelvic Pain
Pediatric research and clinical trials
Digestive health
Neuroscience
Migraine
- Phase 3, multicenter, open-label study to assess the long-term safety and tolerability of rimegepant for the acute treatment of migraine (with or without aura) in children and adolescents ≥ 6 to < 18 years of age
- Phase 3, multicenter, randomized, double-blind, group sequential, placebo-controlled study to assess efficacy and safety of rimegepant for the treatment of migraine (with or without aura) in children and adolescents ≥ 6 to <18 years of age
Oncology & hematology
Medical oncology
- A Phase 2 Study of Inotuzumab Ozogamicin (NSC# 772518) in Children and Young Adults With Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia (B-ALL)
- A Phase 3 Randomized Trial of Inotuzumab Ozogamicin (NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLyv
- A Phase 2 Trial of Chemotherapy Followed by Response-Based Whole Ventricular & Spinal Canal Irradiation (WVSCI) for Patients With Localized Non-Germinomatous Central Nervous System Germ Cell Tumor
- A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors
- A Randomized Phase 3 Interim Response Adapted Trial Comparing Standard Therapy With Immuno-oncology Therapy for Children and Adults With Newly Diagnosed Stage I and II Classic Hodgkin Lymphoma
- A Phase 3 Study of Dinutuximab Added to Intensive Multimodal Therapy for Children With Newly Diagnosed High-Risk Neuroblastoma
- A Randomized Phase 3 Trial of Nivolumab (NSC# 748726) in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma
- Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias
- The Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study
- Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumors (FHWT)
- A Prospective Phase 3 Study of Patients With Newly Diagnosed Very Low-Risk and Low-Risk Fusion Negative Rhabdomyosarcoma
- A Phase 2 Study of Blinatumomab (NSC# 765986, IND# 147294) in Combination with Nivolumab (NSC # 748726, IND# 147294), a Checkpoint Inhibitor of PD-1, in B-ALL Patients Aged ≥ 1 to < 31 Years Old with First Relapse
- A Feasibility and Randomized Phase 2/3 Study of the VEGFR2/MET Inhibitor Cabozantinib in Combination with Cytotoxic Chemotherapy for Newly Diagnosed Osteosarcoma
Surgical oncology